Lysophosphatidic acid accelerates the development of human mast cells.

Effect of lysophosphatidic acid on the follicular development and the ‎expression of lysophosphatidic acid receptor genes during in vitro culture of ‎mouse ovary

Lysophosphatidic acid (LPA) known as a serum-derived growth factor, is involved in several cell physiological functions in the female reproductive system including: oocyte maturation, in vitro fertilization and embryo implantation by its transmembrane G protein-coupled receptors. The aim of the present study was to examine the effect of LPA on in vitro follicular development o...

BAGGA et al LPA AND HUMAN MAST CELL DEVELOPMENT 1 Lysophosphatidic Acid Accelerates the Development of Human Mast Cells

BAGGA et al LPA AND HUMAN MAST CELL DEVELOPMENT 2 Mast cells (MCs) initiate immune responses from mucosal surfaces and perivascular spaces. Stem cell factor (SCF) regulates MC development and viability, but the role of innate serum factors in MC development is unexplored. Cultured cord blood-derived human MCs (hMCs) express mRNA transcripts for all four known receptors for lysophosphatidic acid...

LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release

BACKGROUND Lysophosphatidic acid (LPA) is a bioactive lipid inducing proliferation, differentiation as well as cytokine release by mast cells through G-protein coupled receptors. Recently GPR92/LPA5 was identified as an LPA receptor highly expressed by cells of the immune system, which prompted us to investigate its presence and influence on mast cells. PRINCIPAL FINDINGS Transcript analysis ...

Chemokine Generation by Human Mast Cells for Lysophosphatidic Acid-Mediated IL-4 Regulates MEK Expression Required

P164: The Role of Mast Cells in the Pathogenesis of Anxiety Disorders

Mast cells are a heterogeneous population of granulocytic cells in the immune system. Mast cell granules contain numerous mediators, including neurotransmitters, cytokines, chemokines and lipid-derived factors. In addition to their well-known role in immune inflammation, the presence of mast cells in the meninges and perivascular space in the central nervous system points to their role in brain...